Learn about SEQ-Scope from researcher who imagined it

December 9, 2021  //  FOUND IN: Updates & Resources

The next Taubman Technology Talk will feature Jun Lee, Ph.D. and will take place virtually from 5 p.m. until 6 p.m. on Thursday, Dec. 16.
Lee’s talk, “See Everything Quickly through SEQ-Scope — Microscopic Examination of Spatial Transcriptome,” discusses a technique he and his team have developed.   
It uses high-throughput sequencing, instead of a microscope, to obtain ultra-high-resolution images of gene expression from a tissue slide.
The technology enables a researcher to see every gene expressed, as well single cells and structures within those cells, at incredibly high resolution: 0.6 micrometers or 66 times smaller than a human hair — beating current methods by multiple orders of magnitude.
“Seq-Scope uses spatial barcoding and the Illumina sequencing platform to achieve sub-micron resolution spatial transcriptomics, enabling the visualization of transcriptomic heterogeneity at the cellular and subcellular level in various tissues,” said Lee, associate professor of molecular and integrative physiology.
Lee obtained his Ph.D. in 2006 from Korea Advanced Institute of Science and Technology and received his postdoctoral training at the Department of Pharmacology at the University of California, San Diego. His lab studies the relationship between stress, aging and metabolism.

Click here for free Zoom registration.
Read more about Lee’s work in the Michigan Medicine Health Lab Blog.

Taubman Technology Talks are open to the entire U-M community. They focus on the latest technologies and their applications in medical research, from mass cytometry to microscopy to 3D printing for therapeutic applications.