Psychiatry Grand Rounds to discuss using stem cells to explore genetics underlying neuropsychiatric disease

Combining expertise in stem cell biology, neurobiology and psychiatric genomics, experts have helped to pioneer a new approach by which to study brain disease, establishing that genetic predisposition to psychiatric disorders ranging from schizophrenia to bipolar disorder to autism spectrum disorder can be modeled using patient-specific human induced pluripotent stem cells (hiPSCs).

On May 27 at 10:15 a.m., Kirsten Brennand, Ph.D., will discuss how her laboratory integrates hiPSC-based approaches with CRISPR-mediated genomic engineering strategies, in order to study the impact of patient-specific variants across and between the cell types of the brain. The highly collaborative approach strives to uncover the convergence and synergy arising from the complex interplay of the many risk variants linked to brain disease.

Brennand is an associate professor in the Department of Genetics and Genomic Sciences, Nash Department of Neuroscience and Department of Psychiatry at the Icahn School of Medicine at Mount Sinai in New York.

Her talk will be part of the Psychiatry Grand Rounds presentation.

You can attend her lecture, which will be presented via Zoom. Please click this URL to join and enter password: 531433.