Announcing Michigan Alzheimer’s Disease Center pilot project program

December 4, 2017  //  FOUND IN: Updates & Resources

The Michigan Alzheimer’s Disease Center (MADC) is pleased to announce the availability of “kick starter” research pilot project funds ($35,000 in direct costs) to investigators at U-M, Michigan State University, Wayne State University and Veteran Affairs Ann Arbor Health System (VAAAHS) to test new ideas about the causes and treatment of dementing disorders.

The MADC invites members of the scientific community from these partner institutions to submit applications for pilot project funding. The application deadline is Jan. 15, 2018.

The MADC is committed to funding at least two pilot projects. The MADC and the U-M Claude D. Pepper Older Americans Independence Center are observing the same deadline for research pilot applications. Should a promising application address research issues shared by both centers, the two centers will consider joint funding of the project.

As experts seek to understand and cure Alzheimer’s disease (AD) and related dementias, the MADC considers it among its highest priorities to support innovative, high impact research.

The MADC Pilot Project Program is partially supported by the NIH-funded Alzheimer’s Disease Core Center (ADCC) linking U-M, Michigan State University and Wayne State University. The ADCC’s central theme focuses on identifying, understanding and modulating the numerous non-?-amyloid factors that contribute to brain dysfunction and neurodegeneration.

The proposed research must be relevant to Alzheimer’s disease and/or non-?-amyloid related dementias. Pilot projects should emphasize one or more of the following:

  • Center’s thematic focus on non-?-amyloid factors contributing to neuronal dysfunction and degeneration in dementia
  • Leveraging of resources available at the MADC, U-M Claude Pepper and its Cores and/or co-enrollment of participants in the MADC’s longitudinal cohort
  • Utilization of databases available at the MADC, the Michigan Brain Bank via the MADCC Neuropathology Core, the National Alzheimer’s Coordinating Center (NACC), or the Alzheimer’s Diseases Neuroimaging Initiative (ADNI)
  • Novel methods of detecting/treating cognitive changes
  • Emphasis on studying cognition and unique challenges to diagnosing and treating age-related dementia in underrepresented minorities
  • Focus on aging, frailty and cognitive changes due to aging in older adults

Investigators at all levels are encouraged to apply. Applications received from junior investigators, established investigators new to Alzheimer’s disease or dementia research and investigators who have not previously received pilot project funding through the MADC will be looked upon most favorably. Emphasis will also be given to projects that link researchers from multiple fields and across universities.

Applications should be no more than three pages in length and describe research commensurate with a one-year award. Reviewers will rank proposals based on their potential significance and impact, investigator and investigative team, research plan, likelihood of leading to future NIH or private foundation funding, relevance to AD and related dementias, and relevance to the MADC’s thematic focus on non-?-amyloid factors.

Applicants will be notified of the funding decision by the end of May 2018, with funding available by July 2, 2018. Successful applicants will be required to provide a six-month progress report and a final end-of-year report and presentation to the MADC executive committee. Awardees will present their study findings at the annual MADCC Research Symposium, typically held in June. At the end of the funding period or soon after, the MADC is looking to see one or more publications as a result of the pilot project, and/or continued funding in the form of a new R01 or equivalent grant.

The award can be used for the direct support of salary and/or supplies (no indirect support is allowed). No tuition support is available.

Applications should be submitted through Competition Space.

Three page proposals should include a specific aims section. An abstract, budget and budget justification, biosketch in NIH format, and Other Support/Supplemental document are also required. A checklist with further details and document templates are provided in Competition Space. The proposal and all requested documents should be uploaded as a single PDF.

For questions please contact Arijit Bhaumik at 734-936-8281, email: