UMHS Researchers Making Strides in Cardiovascular Research

April 21, 2016  //  FOUND IN: Our Employees

The American Heart Association is currently funding over $6 million dollars to 44 active research studies at the University of Michigan. Supporting the Washtenaw County Heart Walk is one way we can give back and continue to help fund important research studies such Dr. Shavit’s (below).

How can you help? Please consider supporting the U-M Heart Walk Team by making a donation (here and select the red “give now” button) or participating in the event, which will be held the morning of Saturday, May 7.  If you have any questions, please contact Traci Fischer at 2-1866 or via email at  Thank you for helping make advances in cardiovascular research and education!  


Jordan Shavit, MD, PhD – Assistant Professor of Pediatrics and Communicable Diseases
Project: Identification of Novel Therapeutic Agents and Classes for Treatment of Venous Thromboembolism and Coagulopathy"
AHA Award: $150,000 (1/2014-12/2015)

Dr. Shavit’s research is aimed at identifying new treatments for diseases caused by blood clotting complications, which include clots in the legs and lungs, as well as heart attack and stroke. Most cardiovascular disorders can be treated with several classes of oral medications, with up to ten medications per class. In contrast, there is currently a very limited repertoire of oral medications for the treatment of blood clotting disturbances. Many of the genetic factors underlying these disorders are unknown.

The study uses zebrafish embryos to develop lead molecules that will be candidate medications for treatment of blood clotting disorders, and identify novel genes involved in these processes. This takes advantage of the ability to a screen a whole organism, enabling the identification of multiple classes of agents and genes that act on cells, molecules, or blood vessels. This may vastly expand the repertoire of medications and targets available for therapies, allowing us to significantly individualize treatments to the increasing numbers of patients with multiple medical problems.